THE INFLUENCE OF FRICTIONAL FACING THICKNESS ON THE CONTACT PRESSURE DISTRIBUTION OF MULTI-DISC DRY CLUTCHES




Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits

Hallmarks of cancer, including rapid growth COOKER and aneuploidy, can result in non-oncogene addiction to the proteostasis network that can be exploited clinically.The defining example is the exquisite sensitivity of multiple myeloma (MM) to 20S proteasome inhibitors, such as carfilzomib.However, MM patients invariably acquire resistance to these

read more